Eibar were the first top-tier club to go after a defeat to Sporting Gijon out of this year’s Copa Del Rey.
Eibar rallied from 2-0 down on Thursday in the home leg of the battle but were removed 4-2 on aggregate by the second-division side.
Levante defeated second branch Lugo 2-0 to progress 3-1 on aggregate. Jorge”Coke” Andujar and Raphael Dwamena scored late goals for the hosts at Ciutat de Valencia Stadium.
Athletic Bilbao repeated their 4-0 triumph from the first leg from Huesca to progress 8-0 overall. It was the third win for Athletic this season, at the first match of the team since Argentine coach Eduardo Berizzo was fired.
Real Betis defeated third branch Racing Santander 4-0 to undergo 5-0 on aggregate.
Barcelona, Atletico Madrid and Sevilla went on Wednesday. The draw for the last 16 will be around 13 December.