Williams, 35, played with his full 13-year NFL career with the Bills after being selected in the fifth round of the 2006 draft. He had been selected to the Pro Bowl five times, most recently in 2016.
The longest-tenured player on the Visitor roster, Williams has appeared in 183 career games, the most by any defensive speech in franchise history. He is also one of six players in history to play 1-3 or several seasons.
“I might not be much more thankful to retire because a lifelong Buffalo Bill,” Williams wrote in a letter to fans on the group web site.
Williams’ 48.5 career sacks are the most by a defensive tackle in company history. In 15 games this season, Williams has five sacks and one forced fumble.