Ospreys forwards Nicky Smith and Dan Lydiate are injury doubts to the start of Wales’ Six Nations campaign.
Regional head coach Allen Clarke confirmed Smith and Lydiate is going to be out for between four to six weeks.
Wales begin the Six Nations against France in Paris on Friday, 1 February.
Back-row Lydiate has suffered a recurrence of a knee injury, while loose-head prop Smith suffered an ankle injury in Ospreys’ 51-20 win over Stade Francais on 8 December.
Lydiate’s elbow problem forced him out of Wales’ side to face South Africa on 24 November after being selected.
“They are long-termers so they won’t be from the picture for a few weeks yet,” Clarke said.
“They will be out for a minimum of four to six weeks.
“Dan has suffered a recurrence of an accident on his own bicep so they will be taking a look at this.”
The couple’s potential lack is bad news for Wales coach Warren Gatland.
Scarlets announced the other day fly-half Rhys Patchell (hamstring) and second-row Jake Ball (shoulder) could both be out for as many as six weeks.
Wales and Scarlets fullback Leigh half penny have not played eight weeks since enduring concussion against Australia on 10 November.
Saracens wing Liam Williams have not played as Wales’ win over the Springboks as a result of hamstring problem, although the Irish and British Lion is expected back in early January.
Wales back-row Taulupe Faletau has been sidelined since October with a broken arm and is expected back in first two weeks of January for Bath.