|European Rugby Challenge Cup|
|Venue: Twickenham Stoop Date: Saturday, 12 January Kick off: 15:00 GMT|
|Coverage: Live score updates on BBC local radio and on the BBC Sport website|
Harlequins create eight changes as they face Grenoble aiming to stay top of these European Challenge Cup pool.
Renaldo Bothma returns to the back row using Alex Dombrandt moving to number eight as LeWIS Boyce and certainly will Collier reunite to prop front row.
Ben Tapuai forms a brand new center pairing with Alofa Alofa while Cadan Murley comes in on the wing.
Dave Ward yields to the bench after being suspended by Quins last week after his yellow card against Wasps.
With all sides on two wins out of four games Quins are a point clear at the surface of the pool whereas Grenoble are third.
Grenoble: Cordin; Dupont, Dussartre, Tupuola, Jacquelain; Lucas, Nanette ;Lazar, Tadjer, Gigashvili, Capelli, Geraci, Berruyer, Blanc-Mappaz, Ancely
Replacements: Savonnet, Dardet, Oz, Tuinukuafe, Martel, Glénat, Uberti, Guillemin