World number one Novak Djokovic was knocked out of the BNP Paribas Open in the next round by Philipp Kohlschreiber at Indian Wells.
The Serb, that now holds three of those four Grand Slam titles, has been beaten 6-4 6-4 by the German world number 3-9.
Djokovic struck his racquet in anger after Kohlschreiber – who had lost his past seven games against the 31-year-old – shot the first set.
Britain’s Kyle Edmund be at Radu Albot 6-3 6-3 to reach the final 16.
He will face either Roger Federer or Stan Wawrinka next with the Swiss set meeting in Tuesday’s night session in California.
The game between Djokovic and Kohlschreiber began on Monday but was delayed until Tuesday because of heavy rain.
Kohlschreiber won 72% of first-serve points and saved four of five break points since he closed outside victory.
He will play French 18th seed Gael Monfils in the fourth round.
Nadala three-time champion at Indian Wells, did not face a rest point from the game.
He will play with Serbia’s Filip Krajinovic following Krajinovic, ranked 113, be at 15 th seed Daniil Medvedev 6-3 6-2.
Elsewhere, Canadian 19-year-old Denis Shapovalov rapped on court at his post-match interview later beating Croatian 10th seed seed Marin Cilic.
Shapovalov, seeded 24th at Indian Wells, be at the 2014 US Open champion 6-4 6-2 and will play with Poland’s Hubert Hurkacz next.
Hurzack, ranked 67 from the entire world, fought back to overcome Japanese lion seed Kei Nishikori 4-6 6-4 6-3.