Scrumhalf Dan Robson will miss England’s Six Nations finale Using Scotland on Saturday Due to Disease, with Saracens’ Ben Spencer replacing him in the Group.
Robson won his second cap against Italy, scoring a try from the 57-14 win at Twickenham.
Saracens’ Spencer left his England debut on the tour of South Africa in the summer.
He also gets the nod due to injuries to Danny Care and Richard Wigglesworth.
England will win the Six Nations if they beat Scotland and Grand Slam-chasing Wales lose to Ireland.
Spencer is considered down the pecking order than Care and Wigglesworth, with the knee harm Care picked up on bar obligation costing him a chance to grow his 84 caps.
It means Ben Youngs, who’s started every game at scrumhalf this championship, is set to proceed Care on Saturday as well as eventually become England’s most-capped scrum half.