The 31-year-old is targeting a record seventh title in Miami and faces Argentina’s Federico Delbonis next.
Britain’s Dan Evans plays with Canada’s Denis Shapovalov later on Saturday.
“I’ve had a lot of court time passed between [my] Indian Wells loss in singles and now, tonight’s game,” said 15-time Grand Slam champion Djokovic.
“I’ve done what I need to do the job on. Now it’s just a matter of time and energy to construct the momentum and build which game play.”