The Tottenham striker, a New England Patriots fan, saw them triumph a sixth Super Bowl at Atlanta in February.
“The desire to play at the NFL is not real. It’s something that at 10 or 12 years that I absolutely wish to try,” 25-year-old Kane told ESPN.
“If you play at the Premier League and the World Cup and then you play at the NFL, would you then be considered one of the best sportsmen ever?”
He added:”It dates back again to that drive are the ideal. Even easily down load a game in my phone, can I be the best on earth?”
Kane, who has won 37 England caps, won the Golden Boot at the 2018 World Cup and is Tottenham’s top scorer this year with 20 goals.
“We have had a similar path being doubted when we’re younger – maybe not being the athletes as kids,” Kane said.
“Not many people thought he would become that good or even play at the NFL and he went onto become the most effective ever.
“In that moment, it gave me a real boost to state, look, anything is possible. In the event you’ve got that self-belief and that drive and that hunger, you can perform it.”
Kane will probably be granted an MBE for services to game from the Duke of Cambridge at Buckingham Palace on Thursday.