His Stewart-HAAS Racing teammate, Clint Bowyer, was second (188.659 mph) and Austin Dillon was third (188.501 mph). Joey Logano and Kyle Larson completed the top-five.
SHR swept both Michigan races last season with Clint Bowyer capturing the June victory and Kevin Harvick earning the win in August.
“For the last couple of years, I have been very jealous of the Ford power at Michigan. Now, I’m very excited because I’m with Ford Performance and Stewart-HAAS Racing,” he said.
“I’m looking forward to closing the middle of the season, and who knows, we might even put the No. 41 Mustang in Victory Lane.”
Rounding out the top-10 in practice were Erik Jones, Brad Keselowski, Kurt Busch, Paul Menard and Ricky Stenhouse Jr.
Ryan Blaney got loose while drafting near Bowyer midway through the session but was able to save his No. 12 Ford from hitting the wall.
Both Jones and Chris Buescher had to sit out the final 15 minutes of practice for failing pre-race inspection twice each last weekend at Pocono.