The Stewart-HAAS Racing driver pulled away from the competition in his Ford and finished more than a second ahead of Denny Hamlin. Kyle Larson was third, more than 16 seconds behind Harvick, and was followed by Martin Truex Jr., Daniel Suarez and Kyle Busch on Sunday in the Consumers Energy 400.
There are three races left before the playoffs, including one under the lights Saturday night at Bristol Motor Speedway.
Seven-time champion Jimmie Johnson will have to close the regular season strong to extend his streak of earning a spot in every postseason since the format was created 15 years ago. He started the race tied for the 16th and final spot in the playoffs and had an early setback, making contact with a wall on Lap 15 that damaged his right rear quarter panel and tire, and finished 34th.
Johnson was several laps back for much of the race, but got a potential break for the final spot when Clint Bowyer was knocked out of the race after Paul Menard appeared to bump him. Bowyer began the day 15th in the playoff standings and was 37th at MIS.
Newman, who started the day tied with Johnson in the playoff standings, was 12th in the 38-car field.