From red cards to hat-tricks and own goals to last-minute winners and iconic comebacks, these two teams have a history of creating memorable moments.
The sides go head-to-head again on Saturday (17:30 BST) in an early-season Premier League encounter and it is a chance for players such as Mohamed Salah and Pierre-Emerick Aubameyang to put their stamp on a fixture which has produced plenty of heroes as well as villains.
Here are a few players who have had the biggest impact in the past 15 years.
Thierry Henry (Arsenal)
Legendary Arsenal striker Thierry Henry is widely regarded as one of the club’s greatest players and was integral to their most successful years under Arsene Wenger, including their unbeaten Premier League campaign in 2003-04.
It’s no surprise he had an impact on this fixture, scoring nine goals in 18 appearances against Liverpool. Three of those goals also came in the 83rd minute or later.
But a stand-out moment for the Frenchman came in April 2004, when Liverpool threatened to break that famous unbeaten run in a league meeting at Highbury.
The Reds led 2-1 before Henry completed his hat-trick – his second of the three a sensational solo goal, where he dribbled past several players before slotting the ball past Jerzy Dudek and into the bottom-right corner.
He later scored twice in a 2-1 win at Highbury in 2006 and his last goal against Liverpool came in the 84th minute in a 3-1 victory at Anfield in 2007.
Andrey Arshavin (Arsenal)
Andrey Arshavin was something of an enigma at Arsenal. He was a wonderfully gifted player who often underwhelmed – until THAT match in April 2009.
He became the first opponent to score four goals in a single league match at Anfield since Dennis Westcott in 1946 and was only the sixth player in Premier League history to net four in an away game.
His fourth goal of the match – scored in the 90th minute – was set to be the winner until Liverpool’s Yossi Benayoun equalised with seconds to go.
Martin Skrtel (Liverpool)
The Slovak centre-back had a calendar year to remember when he scored all three of his goals against Arsenal in 2014.
And then again, 10 months later, Skrtel made an impact when he equalised in the 97th minute to give 10-man Liverpool a 2-2 draw after striker Fabio Borini had been sent off in injury time.
Roberto Firmino (Liverpool)
That trio of goals came in the 5-1 thrashing in 2018, where he netted two of them in as many minutes at Anfield. His first was an entertaining ‘no-look’ finish and he completed his hat-trick from the spot.
His solitary goal at Emirates Stadium in December 2017 came in the 71st minute and secured a 3-3 draw after Arsenal had netted three goals in five minutes.
|Top scorers in league fixtures between Liverpool and Arsenal in the Premier League era|
|Robbie Fowler (Liverpool)||13||9||2|
|Roberto Firmino (Liverpool)||8||8||1|
|Thierry Henry (Arsenal)||14||8||1|
|Andrey Arshavin (Arsenal)||6||5||1|
|Olivier Giroud (Arsenal)||10||5||0|
|Peter Crouch (Liverpool)||5||4||1|
|Sadio Mane (Liverpool)||6||4||0|
|Philippe Coutinho (Liverpool)||8||4||0|
|Robin van Persie (Arsenal)||8||4||0|
|Robert Pires (Arsenal)||12||4||0|
Robin van Persie (Arsenal)
Van Persie’s audacious volley from inside the box secured a 2-1 win for the Gunners in a typically dramatic Premier League clash.
It was also his last goal against Liverpool while playing for Arsenal. He had scored four in eight league appearances before netting a further five times against them in all competitions while at Manchester United.
Sadio Mane (Liverpool)
Since joining Liverpool in June 2016, Sadio Mane has scored 59 goals in 123 appearances and is widely regarded as one of the best forwards in the world.
Peter Crouch (Liverpool)
The recently-retired striker netted with his right foot and his left, as well as scoring with his head to complete his rout against the Gunners in a Premier League match at Anfield.
He is also one of just three players to have scored a hat-trick in this fixture since 2004.
Other iconic moments…
Liverpool legend Robbie Fowler netted the fastest Premier League hat-trick against Arsenal in 1994 (four minutes 33 seconds) – a record which stood for 21 years until Mane netted three in two minutes and 56 seconds for Southampton when they demolished Aston Villa in 2015.
That hat-trick earned Fowler his “God” nickname at Liverpool and he went on to score nine goals in 13 appearances against the Gunners.
Another Reds hero was Michael Owen, who scored two goals after the 83rd minute to give Liverpool victory in the 2001 FA Cup final at Millennium Stadium.
There have been plenty of memorable moments at Anfield. Neil Mellor’s stunning strike in 2004 earned Liverpool a last-gasp win in the Premier League, while Arsenal’s Julio Baptista scored four goals and had a penalty saved in a 6-3 League Cup victory in 2007.
There has also been plenty of villains. Joe Cole had a memorable debut for Liverpool when he was sent off in 2010 during Roy Hodgson’s first game in charge – a match in which Arsenal debutant Laurent Koscielny was also shown red. An own goal from Pepe Reina in the last minute ensured the Gunners got a 1-1 draw.
And there was the game at Highbury in 2000 which saw Gary McAllister, Didi Hamann and Patrick Vieira given their marching orders, before another three red cards were shown to Martin Keown, Dennis Bergkamp and Jamie Carragher at the same ground in 2002.
And we can’t go without mentioning…
“Thomas charging through the midfield. Thomas… it’s up for grabs now!”
These were commentator Brian Moore’s words to describe arguably the most dramatic ending to a top-flight season of all time.
It meant that an Arsenal win by two or more goals would see them pip Liverpool to the title. Liverpool had not lost by two or more goals at Anfield in three years, and Arsenal had not won at the ground in 15.
Alan Smith’s 52nd-minute header gave Arsenal hope, but these were quickly evaporating as the game entered injury time. Cue Thomas, who, as Moore described, ran through from midfield, collected a Smith flick-on and fired past home goalkeeper Bruce Grobbelaar to win the game and the title.