West Ham Women usually play at Rush Green, with a capacity of 2,000.
They are the latest WSL side to switch a fixture to a bigger venue following the Women’s World Cup, with Manchester City and Chelsea the first to do so.
Managing director Jack Sullivan said it is “another historic day” for the side.
“After the success of last season and walking out at Wembley, it will be a great opportunity to play on an iconic stage – our own home ground – for the first time ever, engaging with the West Ham fans who we urge to come and get behind the team,” said Sullivan.
“It promises to be a magnificent showcase for West Ham United and women’s football as a whole.”
Relocating matches to bigger venues is nothing new in the women’s game in England, with Arsenal sealing their league title at Brighton’s Amex Stadium in April in front of a new WSL record crowd of 5,265.
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