Oxford will entertain Sunderland in an all-League One encounter.
For the first time in the competition’s 59-year history, no Championship side made it through to the fourth round.
Matches are to be played in the week commencing 28 October.
Carabao Cup fourth round draw in full:
Everton v Watford
Aston Villa v Wolverhampton Wanderers
Burton v Leicester
Crawley v Colchester
Chelsea v Manchester United
Oxford v Sunderland